Brutal scene! The refraction is the big killer, and the sizzling refuses to go away without really high settings - both separate issues, both contribute to the slow speed. I'm using Apprentice so I can only render at 1280x720, so my baseline to render your scene ( on an old 12-core ) is about 1 hour. What will help to reduce render times ( for this scene, not nec. all scenes ) is to use higher raytrace samples instead of higher pixel samples, to clean up noise. But you also need to set a lowe